SS-31 (Elamipretide), available in premium 5mg to 50mg lyophilized vials, is a groundbreaking, mitochondria-targeted tetrapeptide that functions as a cellular “First Aid Kit.” Unlike generic antioxidants that remain in the cytosol, SS-31’s unique Szeto-Schiller motif allows it to readily cross cell membranes and specifically concentrate within the mitochondrial inner membrane (IMM). Here, it binds directly to **Cardiolipin**, a crucial phospholipid. By stabilizing Cardiolipin, SS-31 restores the integrity of the mitochondrial electron transport chain, optimizes ATP (energy) production, and, most importantly, dramatically reduces the production of deadly **Reactive Oxygen Species (ROS)** at their source.
Key Features & Research Benefits
🛡️
Mitochondrial Homing
Possesses an extraordinary affinity for the mitochondrial inner membrane. It bypasses the cytosol entirely, delivering therapeutic action precisely where 90% of cellular ROS is generated.
🤝
Cardiolipin Stabilization
Forms a strong, synergistic bond with Cardiolipin. This crucial interaction prevents Cardiolipin oxidation and maintains the cristae structure necessary for efficient electron transport.
源
Source ROS Scavenging
Functions as a radical scavenger at the very source of production. By optimizing electron flow, it reduces the electron leakage that leads to superoxide formation, preventing oxidative damage before it begins.
🔋
ATP Restoration
Restores the functionality of aged or dysfunctional mitochondria. In various research models, SS-31 administration has shown to significantly boost mitochondrial respiration and cellular ATP levels.
⏳
Reversing Cellular Aging
Directly addresses the Mitochondrial Theory of Aging. By restoring mitochondrial function to a youthful state, it provides a systemic anti-aging effect and reduces cellular senescence.
💎
Verified High Purity
Synthesized using standard solid-phase peptide synthesis (SPPS) protocols, ensuring a ≥99.0% HPLC-verified purity level. Ideal for sensitive mitochondrial function and aging research.
How It Works: The Szeto-Schiller Motif
SS-31 (Elamipretide) is a peptide masterpiece derived from the Szeto-Schiller (SS) motif, a small sequence known for its ability to penetrate membranes independently of concentration. Its structure features alternating aromatic and basic amino acid residues. This specific configuration gives it a slight net positive charge and hydrophobicity, allowing it to glide across the cell’s outer membrane and the mitochondrial outer membrane.
Once inside the intermembrane space, its true hard-core mechanism is unleashed. It “homes in” on the Mitochondrial Inner Membrane (IMM), the site of the Electron Transport Chain (ETC). The IMM is rich in a unique phospholipid called Cardiolipin. Cardiolipin is essential for anchoring the protein complexes of the ETC (Complexes I-V) into supercomplexes, or “respirasomes.” This organization is crucial for efficient electron flow and ATP production.
During aging or disease, Cardiolipin becomes oxidized and moves out of the inner membrane, causing the respirasomes to fall apart. This leads to inefficient electron transfer (electron leakage), resulting in a spike in Reactive Oxygen Species (ROS) production and a catastrophic drop in ATP levels (a “Mitochondrial Energy Crisis”).
SS-31 acts as a stabilization agent by directly binding to Cardiolipin. It prevents Cardiolipin from oxidizing and keeps it anchored in the IMM. By maintaining respirasome integrity, SS-31 “re-wires” theElectron Transport Chain, restoring efficient electron flow, maximizing ATP output, and effectively quenching ROS production right at its source. This direct optimization of mitochondrial bioenergetics makes SS-31 the ultimate tool for reversing age-related mitochondrial dysfunction.
🧪 What’s In The Vial
Active Compound: SS-31 (Elamipretide / MTP-131)
State: Sterile, Lyophilized Powder
Format: Multi-dose Research Vials
Net Contents: As selected (5mg – 50mg)
Purity: ≥99.0% (HPLC Verified)
👩🔬 Who Uses It
Anti-Aging & Longevity Researchers
Mitochondrial Function Specialists
Neurodegeneration Labs (Alzheimer’s/Parkinson’s)
Cardiovascular & Heart Failure Labs
Metabolic Syndrome Scientists
🔗 Best Paired With
Sterile Bacteriostatic Water (BAC)
Precision Laboratory Pipettes
NAD+ Precursors (NMN / NR for synergy)
GHK-Cu / MOTS-c (Advanced Anti-Aging)
As Mentioned On
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